I second the OCW test method. I did a bunch of ladder tests early on in trying to work up a good charge and all I got was shit results. I was also doing it at 300 yards. After consulting one of the club bench rest champions, I decided to do the OCW method, which calls for 3 shots. I also did it at 100 yards to minimize any effects of wind, and rather than only doing 3 shots, I loaded six for each charge weight. That way, I would have more statistical data and I would have an extra round in case one were a flyer (shooter error). Now I am getting 1/2 MOA out of my gas gun.
Here is what I found: The ladder test method sucked for me. Think about it. If you are shooting a load that produces a 2 minute group, you have no idea where that particular bullet is going to land within the 2 minute radius of that load. So a single shot at a particular load is not a good indicator. Also, you will not get a vertical string by only varying the powder charge because the harmonics of a barrel do not just go up and down. The harmonics of a barrel oscillate in the x and y planes, like a big circle. This is why firing multiple shots from the same powder charge is beneficial. Each charge gets its own target, and each target gets several shots. This gives you a true indication of the dispersion of a certain load.
Then after doing the OCW test, take the best group and then work up a new test to experiment with seating depth. Each seating depth gets its own target and each target gets several rounds. Once you have it nicely worked up at 100, then take it out farther if you want to continue fine tuning the load.