Assuming your rifle is a Weatherby and has the WBY free bore I have had best luck with OAL of 3.170 in three WBY rifles with the Barnes TSX.
I used to use RL-22 but have switched to Retumbo, start at 75 grains and work up if you are using Norma WBY brass and have the long throated rifle.
Retumbo, RL-25, RL-22, Ramshot Magnum, IMR 7828 all work well with this cartridge bullet combo.
I find the best accuracy just past 3600 fps with 26" tubes.
Have used CCI, Win & Fed mag primers and no complaints with any of them.
The 100gr TSX and the 257 WBY Mag are perfect match.