Like everyone else said, if not subs then shoot how you will be shooting. Cans can and will alter zeros, harmonics, and MV. Some aren't as much as others. I would want to know if there was any difference either way and wouldn't want a load that shot much different one way ot the other. Like in La we cant hunt suppressed, SO, I would want to make sure I knew my dope and zero with out it but if shooting with it on I want to know how it will react. I wont be shooting one way or the other 100% of the time. Cans can make it tougher to get through some places and be heavier. Use it how you intend to shoot it and note the difference it does make. And make sure its repeatable.