With the CDS dials, if you account for all the variables: bullet weight, BC value, velocity, and air pressure to name a few; you should get close enough to get a hit on the vitals of a deer. Big changes in air pressure due to elevation changes and temperature can have a big impact on the ballistic curve. Check out JBM ballistics and just play around with the variables on the calculator and you can get an idea of how much of an impact changes of a different value have on the point of impact. CDS dials are not meant for long range precision; but are good for intermediate hunting ranges. Personally I have not taken a shot on an animal much past 300 yards. In this range, the CDS dials should work for you if you account for the variables.