Ackley improving the .22-250 case will net you performance parallel to a .220Swift.
IE, 55s will run right near 4K, from a .22-250AI, minus the case stretching of the bottlenecked Swift case. I have a few hardcore coyote hunting pards who've been there & done that, and they run .22-250AIs with 55s. IIRC, they are running 1:12 twists with the 55s, which nets a very efficient use of that powder capacity. Accuracy is phenomenal, terminal performance is excellent, and case stretch/upkeep is nill. Trim once after fireforming, if at all, and rock on. Feeding from a standard BDL magazine is fine...
That said, I've also got some pards who run fast, 1:8" twist .22-250AIs with 75Amaxs, and they're plenty tickled, too. ~3350fps is a realistic high end to expect, from the .250AI.
From 300yds, on out, the fast twist heavies will really begin to shine in windy conditions. And they'll be hittin'' like a dang freight train, from the muzzle, on out. But those 55s still get to 500yds plenty quick, with enough gusto, too. Predator hunting here in NY, shots will be in that <300yd range, much more often, than not.
Pick your poison...
Course, if ya wanna go "full retard", do a fast twist .22-243Imp like me, LOL! Then, you're stepping in a whole nutha' league of badazzery with .224caliber heavies. Add another 300fps to how fast a .22-250AI will launch the 75s, and you might just develop a thirst to sip that Koolaid...
But again, .22-250AI:
1:8 twist, 75s @ ~3300
1:12 twist, 55s @ ~4000
Thats about what you're lookin' at, from a 26" tube...
Good luck & have fun deciding!!!