If you're loading 120-130gr powders, run it. Most 300wsm benchest shooters are loading with 16/4350 due to shorter preasure curve/long barrel accuracy trend. They run LONG barrels so still get the high velocity. Rl23/rl26 are better suited for the prc with 140gr bullets. H4831sc, 7828, 7977, H1000, N565, anything in the medium/medium-slow burn rate work well. If you're loading 147-156gr bullets, you definitely want to run slow magnum powders.