Short answer, yes. Very few of my scopes and loads will zero-out dead-nuts on the bull. Atmospheric changes happen, burn rates vary from lot-to-lot, bullets vary from lot-to-lot, and it can cause slight shifts like that. And sometimes you might be slightly "off" that day, or your eyes might be tired that day, it's just any number of things, but IMO, yes, that's an acceptable zero.
The way I look at it is, if you're only 1/4-1/2" off center, I don't think a deer's heart will know the difference when the bullet turns it into jello moving through it at 1,500+ FPS.