As a function of forest fires and wanting to meet a weekly training schedule, I have done more miles than I would like in a respirator - simple N95 as well as a dual P95 cartridge FM. I have also done a fair amount of reading on the subject.
Couple thoughts -
A) It does not simulate altitude. Altitude would mean less O2 per given unit of air and a fixed ratio of CO2.
B) It does represent CO2 build up / over saturation
C) You’re going to tax your body. Make sure you’re in shape for that. A CO2 build up plus exertion can be a recipe for a heart attack. From what I could gather / guesstimate it makes it @ 25% harder from the standpoint of CO2 alone - add heat or other stress - you’re going to start to really tax your body.
D) It is uncomfortable and annoying as shit - the weight of a dual filter unit, sweating, blowing goo in your mask, 90+ degrees and smoke. You know it is working if you hear the cartridges ‘click’ and the flow of resistance change with each direction of your breathing. I was good for 25 - 30 miles a week, but I was really happy when the rains came and the fires were extinguished for the year. It was not uncommon to have a slight headache for a bit after the run. I did get behind the curve once while masked and got heat stroke - wasn’t fun, but self recovery was attained after a few hours.
Definitely read about the effects of CO2 on the body and take a little caution with this; if your not in pretty good shape - ease into it.