Just be wary of bedbugs.....not kidding.
I'll not soon forget our trip to the Keys in April of 2017.
On return trip traffic on I95 held us up and ended up having to overnight at the Red Roof Inn in Yemassee,SC. The Hampton Inn was litterally next door, but didn't have the rooms we needed, they were booked up. I usually stay at the higher end lodgings like Hampton Inn.
Upon waking the next morning my elderly mother found a bedbug on her bedding. I went a tad berserk. Complaints to the manager were met with indifference. They basically said we probably brought them with us. I'm not saying that's impossible, but my 84 year old mother remembers when bedbugs were a real issue back in the post Depression South. She is OCD about such things on a trip, and had went over our lodgings in the Keys with a fine tooth comb the first few days we were there, so I pretty well ruled that out.
Long story short, I wouldn't let anyone put any luggage or brought bedding in the cab of my truck after we checked out of the Red Bedbug Inn.
I threatened to burn all our clothes before they could come in the house, but Momma and the wife wenthrough everything in the yard, and put it straight in the steam wash, and high heat dryer.
I know you live where everything that bites will kill you dead, but once you get bedbugs they are damn hard to get rid of without fire.
I use HomeAway, VRBO, and if I stay at a hotel, I'll usually pick a high end joint in a good part of town. Hapton Inn is usually a safe bet, and I've always been pleased with their service.