If a bullet is shooting 2 moa with an arbitrary charge weight, I am not doing to do a full work up with it. Its not going to tighten up top shoot like the other load. IMO.
I'm fairly quick to write stuff off that doesn't work and not waste time with it. And I'm not telling you what to do, just sharing some experiences I've had. I have made the same bullets, primers, and cases at the same seating depth shoot 20 shot groups that were 0.45-0.6 MOA all the way up to 2-3 MOA by adjusting powder type and charge weight. No bullshit, all within the expected burn rate for the cartridge, all within published load data. FWIW I've never experienced a "high node". Good powders have a flatter slope, but all of them that I've tested dispersion increases with increased powder charge. So often if something is not shooting great, I'll drop a grain and see if it helps dramatically. Sometimes it does.
After having seen the aforementioned 0.5-3 MOA from the same components, I will try 2-3 different powders before I nix a bullet for a particular barrel. And it's not always bad bullets. Sometimes they just aren't happy with something that happens in that barrel and will shoot fine in another. Throat geometry, twist rate variation, bore/groove ratios or dimensions, etc...
