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Enough to matter? Temp. Sensitivity of IMR 4350 between 50-90?

It isn't horrible but really a bigger factor if you are chasing the upper edge of performance. Hot loads can become dangerous quickly with powders like IMR 4350, RL 17 and those that are less tolerant of temp swings. I find that if you can find IMR 4350 that usually 4451 is close as well and it is much more stable. Similar results ( speed wise but slightly higher SD/ES's for me which is not as big a deal depending on distances you are shooting....under 600 your gonna be ok) Alliant RL 16 is worth looking for if you see it. Arguably every bit as good and easy to work with as H4350 and stable.
 
What are you loading for?
For 6.5 Creedmoor and .260 we went from H4350 to RL16. More temp stable and we have Found good loads easily for all our rifles. And H4350 is more temp stable than IMR 4350.Left the IMRs ages ago.
Same thing with RL23 for my 7WSM. Made by the same company that makes
RL16. Very temp stable and easy to find loads for the 7WSM.
 
Take this with a grain of salt, but I have a friend who loaded with IMR 4350 for his 6.5 Creedmoor and it seemed like everytime we went to the range, his velocities were always changing. Sometimes it was just a few FPS, sometimes it was significant. I don't know anything about his reloading practices, and he still seems to have abnormal velocity fluctuations with H4350, so I have a feeling it's more than just the powder he's using.

Personally, I use RL16 for my 6.5 Creedmoor. In my testing, it was every bit as temp stable as H4350 and I got a little bump in velocity.
 
Found someone to go in on an order from PV., to ease the pain of shipping cost. My Tikka CTR did not especially care for imr 4451 and rdf's, hopefully H 4350 will do. Wish I knew what Horn. Factory load consisted of, it shoots that stuff lights out.
 
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Found someone to go in on an order from PV., to ease the pain of shipping cost. My Tikka CTR did not especially care for imr 4451 and rdf's, hopefully H 4350 will do. Wish I knew what Horn. Factory load consisted of, it shoots that stuff lights out.

Hornady used to publish their load data on the boxes of 120 and 140 AMAX. I remember they used H4350 for the 140s, but they've since switched to a proprietary powder you can't buy off the shelf