Take this with a grain of salt, but I have a friend who loaded with IMR 4350 for his 6.5 Creedmoor and it seemed like everytime we went to the range, his velocities were always changing. Sometimes it was just a few FPS, sometimes it was significant. I don't know anything about his reloading practices, and he still seems to have abnormal velocity fluctuations with H4350, so I have a feeling it's more than just the powder he's using.
Personally, I use RL16 for my 6.5 Creedmoor. In my testing, it was every bit as temp stable as H4350 and I got a little bump in velocity.