I have tried it with the 185s side by side with Varget. The 4320 gave very close but ever so slightly higher velocity than Varget on an equal weight basis. ES/SD numbers looked similar. The 4320 gave me a blown primer at the highest load, whereas Varget showed no obvious pressure signs, even though the velocity was close for the same charge weight. So although the 4320 is generally listed as slightly slower than Varget, it seems to develop pressure a little faster in my hands. The vertical with the Varget was also just slightly better at 300 yd. The final Varget load was Lapua brass, Fed 210 primer, 44.4 gr Varget, 185 Juggernaut seated .020" off, .002 nk tension, MV ~ 2770 fps out of a 30" Bartlein SS 5R .299/.308 barrel. My impression is that the IMR4320 would have worked almost as well at something like 44.1-44.2 gr. I'd use it in a heartbeat if I didn't still have some Varget left.