Oh, I suppose so.
The least invasive are clamp-ring blocks with a globe front, but I'm not aware of anybody that makes a clamp block for less than about a 0.750" tennon. There's always custom though.
Installing decent drill/tap irons should not be particularly material to accuracy if done correctly. The screws are probably #6-48, which is not much of a hole...unless drilled too deeply.
Put another way: there were
generations of mid- and Long-range National records set with screw-mounted front sight blocks on rifles like the 1903 and Model 70.
The bigger question, particularly if you go with something like a "buckhorn/bead" combination, is whether you can even AIM within 3 MOA. Depends on the exact setup, but that's a pretty tall order, to be honest.
A rear aperture "peep" sight, on the other hand, is plenty workable to 1 MOA, even with exposed blade front posts, without a whole lot of practice.
Stare at this for a minute:
https://warner-tool.com/collections/rifle-hardware/products/wtc-iron-sight-scope-combo
...and see that the side-mount base for something like an RPA or Redfield rear sight has nothing to do with the scope rail. The scope comes off (as it would anyway), the rear iron goes on and gets torqued to spec, and you resume shooting. Rinse/reverse to put the scope back on. With good equipment, and just a modicum of care on the part of the armorer and/or shooter, the two systems will repeat well within 1 MOA of their prior zero.
-Nate