Every rifle or situation can be different. I've established loads in 25 shots that have held through the barel speedup and were great. I've also developed loads on 5R cut barrels or a proof carbon that never did speed up. I've also developed loads that turned hot after the barrel speed, which I have brought back in by coating bullets, or dropping powder, sometimes it is simple, other times it is a PIA.
Today for the most part I find a load that shoots right off, then finalize after breakin(speedup).
My last build, a Dasher shooting 110's at 2820 with hydro formed brass was a hammer, it sped up 55-60 fps on speed up, still amazing. Then all 300 pcs of brass I put in service were fired, after processing, the load sped up 20 fps, now the load is on the verge of shooting good and faltering, no good. So I start pulling powder to get back to around 2875 fps, that did not work with the powder I'm using, as now I am gassing the shoulders and subsequently the chamber. Adding .3gr of powder to original has me back on track, at around 2925 fps.
It boils down to your preference.