How precise do you want/need to be?
I pick a bullet that suits my needs (BC, weight, expansion if hunting, etc...) and almost always you can vary powder charges with a 0.010-0.025" jump to the rifling and can get sub 1/2 MOA with a "match" barrel in a bolt gun. Very rare exception that I have to change bullet brand/model to get it to shoot well.
You can burn up half a barrel's life trying every little variable out to see what's "best". I go for 1/2 MOA elevation spread @ 300 or 400yd and call it good.