I'm a huge fan of the 243 for deer/antelope size animals. I dont have one since I use a 257 Roberts in a Win Featherweight but I built one for my wife.
She broke her back and has three rods between her shoulder blades and cant take a lot of recoil. I had to find her a rifle. I had a Model 70 action laying around so I built her 243. Extremely accurate and effective on deer size animals.
Dont let any one tell you they are too light for deer/antelope. Just select the proper bullet. Bergers work, we used the 87 gr VLD -Hunting but found they tear up too much meat. We went to the Hornady 85 Gr. InterBonds and never looked back. I used a 1:10 twist barrel on her rifle, I think I should have went to a faster twist, but the success she has with the Hornady, I cant justify a barrel swap.
Shot at about 275 yards:
This guy was taken at 540 yards:
I since bought her a Ruger Precision Rifle in 6.5 CM for elk hunting. I fell in love with the 6.5 CM so I bought a Ruger American Predator in 6.5. Then bought the wife a RAP in 204 Ruger because I was impressed with the out of the box accuracy of the Predator.
Check out the YouTube videos on the RAP, they are that good. For the price ($400) you'd be hard pressed to find a better moderately priced, accurate rifle.
The RAP in 243 comes with a 1:9 twist barrel so you can go with the better 105 gr bullets.