There's so many variables we reloaders have to deal with. We even know that bullets can vary on base to ogive somewhat even in the same manufacturing lot. Any more, I just choose bullets with a tangential or hybrid ogive where minor seating deviations don't really show up as increased group sizes. This way, I get to spend more time shooting without constantly sweating minor details at the loading bench.
If I was to try some VLD secant ogive bullets, i would start at .040" off the lands and go shorter from there. Berger has an article on their site that says if VLDs refuse to shoot well at the lands in your rifle, the back up in .040" increments until you find the sweet spot. As a barrel throat errodes, I surely don't want to have to keep tweaking my overall length just to maintain a tight group from a finicky load developed right at the lands. If I have a load that doesn't mind jumping, then surely +/- .005" on seating depth isn't going to ruin a good group.