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Once optimal seating depth is found.....

I found a great powder charge then seating depth combination for my MPA 6.5 Creedmoor.
The problem is that I am getting ejector marks on the brass, which I am in the process of troubleshooting.

My question is, what happens to the accuracy once I start backing off the powder load?
I know that elevation will need to be adjusted on the scope.
But I am talking about the group size. If I shoot 41.0 grains and lets say 2.207 seating depth then what happens if I go to 39 grains?
Will it affect my groups? Or can I theoretically keep the same seating depth and not have to go through that seating depth exercise again.
Again, not talking about elevation, I can adjust for that easily. Will my tight groups be affected.

Thank you in advance.
39.77