The only way these cyberpunk semiautos and revolvers would actually look cool and fit in, is with big, jet black leather greatcoats, Neo haircuts, smart glasses that project a blue holographic interface in front of the wearer, and starships docking and taking off every minute from a colossal orbital station on the horizon LOL. That is why the market for the Rhino and other similar guns remained on the niche end of the firearms world.
The only exception to this are KelTec bullpup shotguns. THESE look cool anywhere, anytime.