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I have used RL-25 in 243 with the 105/115. Worked well when the temps were on the cool side. On warm days the instability of the powder raised its ugly head. It was frustrating trying too figure how fast the bullets were going.
George Gardner from GAP is said to use RL-25 is his 243 WIN with 115 moly DTACS. My buddy used it as we'll with great results. Supposed to be able to get you to 3,000 fps plus. I use H-1000 personally.
I used 46gr of RE25 with the 115 DTAC. I got .3 MOA and 3050fps on a cool day but pressure signs like crazy when the ambient temp exceeded 70 degrees. Had to keep loads on ice during matches. 47.3 grains was even tighter groups but had to be cold outside. Ended up breaking an ejector and spring, ruined a lot of Lapua brass. I'm done with Alliant powders.