We've killed em with 340wby, 300wby, 300win mag, 30-06, 270, 7 Rem Mag, 280 Rem, 260Rem, muzzleloader, and bow, from 7 steps to nearly 700 yards. I've seen my buddies shoot them with calibers as small as 243. It's way more important to shoot a good bullet and place said bullet where it should be...