For those two calibers, no difference.
The RL1100 will only go up to 308 WIN length cases. The S1050 goes up to 30-06 length.
Everything else is the same, as far as capabilities and interchange of caliber conversion and such.
Bought from Cameraland NY in June of 2019 and it never got on a rifle.
It is a Gen1, which should be obvious since it doesn't say Gen2 on the box but wanted to be clear.
Asking $ 450 TYD Payment through Zelle, Venmo or USPS MO.