Re: .22 with a muzzle brake?
other than looks, or to have the threads protected for "other attachments" if a threaded on brake, not much recoil there to try to tame. whatever (any) muzzle jump would obviously be improved even closer to "0", but the brake would IMO be a waste to use on a .22 for any recoil reasons, even on semi / full auto applications.
maybe it can act as a tuner if your lucky enough to have it weigh enough and be effective as such at the end of the barrel.