Re: 260 + H4350 + 130 Bergers....how much powder?
You might find your accuracy node around 44 or 45 but I would certainly start a grain or two lower and work up since every rifle is different. Your node may be 43.2 but if you start at 44 you'll never find it and quickly get discouraged. If using Lapua brass, absolutely start lower as they tend to run pretty hot. My accuracy node with Lapua brass and 142s is a healthy half grain lighter than Remington, Hornady, Winchester, etc.