The Australian manufacture of Varget recommends 48 grains as a starting load up to 50 grains max compressed load.
However there is no reason you can't stick with 46 if you are happy with it.
If you look up ADI loading data Hogden Varget is a powder called AR 2208 http://www.adi-limited.com/handloaders-guide/
download the guide and if you look at the powder equivalents page at the bottom of the left menu you will be able to work out all the Hogden powders made by ADI .
I would post the data but posting images on this site is difficult .
Hogdens data only starts at 150 grain bullets in 308W I think.
I would go for a faster powder for a 110 bullet in a 308 case maybe Hogden Benchmark which is Benchmark 2 in the guide.
<div class="ubbcode-block"><div class="ubbcode-header">Originally Posted By: jasonk</div><div class="ubbcode-body">Where did you find the load data that told you to use 46gr of Varget? </div></div>
Hodgdon says 48 starting 50C max for a Barnes 110gr. With 48gr the powder filled the case halfway up the neck and that freaked me out so I backed off 2 grains for a starting load. Heres my test group
That's better Hogden data than I have . The group looks good
Different powder types have different load densities so where they sit in the case is not really a huge issue . Its the weight of charge matched to the particular round and bullet weight etc that is more critical. I find a charge weight that just sits under the base of the bullet usually shoots good but there is no hard and fast rule on that.
Recoil also becomes a factor . Although the faster loads might shoot better at longer ranges than the lighter loads do due to less verticle stringing and better wind bucking and more retained velocity to stay supersonic as far out as possible.