Here's the thing; I don't believe in putting different chamberings into an AR from what it was designed for. Cycling issues would be my main concern, I've seen some with my Buddy's 300BO and 9mm AR's.
For a Pistol Caliber Carbine, I'd rather get the Ruger PC Carbine and be done with it. It is a caliber-specific design, inexpensive, the reviews are great, and rumors suggest possible additional later offerings in 45ACP, and maybe..., maybe a 40cal. Mine is on order and will be sharing 17rd magazines with my Ruger American Pistol 9 Pro.
If you can't find a versatile selection of .223/5.56 ammunition for your AR, I'd look a little harder; either that, or maybe you're asking more from the system than it's really going to be good for. I've tried Uppers from 16" to 24" and bullet weights from 50gr to 75gr; and there's a lot of potential there.
Suppressors? They don't interest me (too much big, nosy government interference), and if I want to shoot subsonics, I'll be using the .22LR.
For full bore cartridges, maybe an AR-10/Stag 10; I'm still contemplating my first one, and dithering between 6.5CM and .260 Rem.
Greg