There are really only two things to remember. One is that different charges cause the barrel to flex differently and second, you want a charge that causes the bullet to leave the barrel at the most efficient "harmonic".
All the single charge ladder test does is identify the different "harmonic nodes" or where the barrel seems to naturally want to be when the bullet leaves. That's why you will see groups where each bullet had a far different charge weight.
Ideally, one uses the old Creighton Audette Ladder test of one shot per load, and then verifies it with a fine tuning session using 3-5 shots per charge which then is only varied by a couple of tenths above or below the loads identified in the ladder.
You could accomplish the same thing if you merely took the starting load for any given caliber/bullet/powder combination and then shot 3-5 shot groups, increasing the load by .2 gr until you found the magic group or maxed the load for the powder. That would take far more components than the ladder, OCW, or combination of both to reach your goal.
Just like every car seems to have a speed it likes to travel on the freeway where it feels best, doesn't seem to be straining, and perhaps gives the best fuel mileage, same for rifle loads and accuracy.