What, cartridge, powder, temperature, rifle... All will pay a part in the answer.
I shot a 7mm RM with AA3100 with BR2s with good results out to 1,200 yards. I got hang fires with a 6.5 RM using R19 while trying BR2s and Standard 200s. This occurred even though I was over 10 grains more powder in the 7mm RM than the 6.5 RM.
Good Luck
Jerry