Dan knows the most on the subject.
You are over pressure at 45.4 in Lapua brass, although that's where your node is. When it gets hotter outside you'll see it. I start seeing pressure signs around 45.7 in hot weather with 168 hybrids in Lapua brass with Varget. You can run that load if you want, but I wouldn't. The brass will probably wear out pretty quick.
Anyway, most of the info out there about 178's points to 44.0-ish working well. Not coincidentally that's 3% EXACTLY below the 45.4 grain load on your target, which is where Dan's method would predict it to be. I'd try that. Maybe go 43.6, 44.0, 44.4 and see how that looks. Bet it's good, the OCW method has worked well for many people.
Nothing wrong with 4 or 5 shot groups if you like, they're your components to burn.