I have shot the high and low culls against cartridges pulled from the mean, but only at 100 yds.
When I reload, heavier cases with the same charge as lighter cases go faster across the Chrono. I set up my range boxes in 10 round sorted groups.
I just started shooting 6ooyds and just don't want to have fliers if I can help it.
I sight it at 100yds, take it to a meet for 600.
Like I said, other than slightly opened groups with the extremes I couldn't see anything significant @ 100 yds where I do most of my shooting.
Now, steel cased X39 and 54R foreign ammo groups are better sorted. The steel jacketed projectiles add a mix of a few grains.
Pulled down and put back together (Mexican Match) better yet.
I put together a 6.8 at a club meeting in Florida. Brought 3 boxes of Federal cheap 115gr. Sorted out 20 rounds of the 60 and they "Shot better" than a left over box, again, just at 100 yds.
I sort cases, sort bullets (have found mixed up weights in bulk bullets) weigh charges. Does it matter? For minimal effort it seems worth it to me. Now, I don't weigh primers

Most of the weight of a primer ain't the mix.
I am playing with a 22 Nosler right now. 22N cases and necked down 6mm Hagar cases. Drastic difference in weight and capacity.
Think that would matter? 12 to 13% difference in weight, about 3% different in capacity even once fired and resized.
As far as Scientific data about case weight/powder capacity, just look at the .223, the .223AI, the 22 Nosler.
Primary difference is powder capacity. Same with the many variations in 6.5 cartridges.
If 7% between the 223 and 223AI makes a difference, would 1 or 2% capacity be negligible?