That depends on how big the acceptable hit zone is.
If its a 8" hit zone....aim dead on. If your threading a keyhole....you need to know your ballistic arc in relation to your sight height.
Looking directly at the bull through the optic....do you need to hold over of hold under here to hit it?
Just because it's closer in doesn't necessarily mean it's a hold under.
Run your data on a ballistic solver. You will see where near and far zeros are and everything in between.