There have been thousands of compounds with in vitro data showing activity against viruses, nearly all of which failed when tested in real patients. That is why you have to do the trials. Again, it can be worth it to accept some risks even for prophylaxis, if the drug works for prophylaxis (and there is data that HCQ does for malaria).
I’m not getting into your transphobia except to say that it’s sad.
How many deaths and destroyed lives from a non functioning economy do you accept to "feel' that your science was validated?
"We have to destroy the village in order to save it" seems to be your heading.
You dont see the problem because you, PegMeNow, like Dr Falsey, havent missed a paycheck.