Yes, it is entirely possible. POI can vary both for environmental factors like the effect of wind and for different stuff like how a particular barrel vibrates in response to both forces within and the stress they induce in the barrel itself.
I see you are still seeking reasons for your all over the place 300 yard shooting. That machine gun ammo you are using is not doing your groups any favors and banging away at 300, I don't feel is the way to go for you. I elected to try another method when I returned to precision shooting after about a 20 year layoff and a change in equipment from open sighted pistols to rifles. I did like I did when I was learning handgun silhouette. Work on the 50 yard chickens till you not only hit them frequently, but also could not miss them. Then move out to the 100 yard pigs, and so on to the 200 meter rams. You should follow the same path.
Move up to 100 yards. Now concentrate on your fundamentals and master them there. You will be able to monitor your progress by how consistent your groups are and how, not by magic but by hard work, your groups are shrinking. I shot my best group to date on my second day out with my new gun. 0.302" center to center for 5 shots at 100 yds. I was proud of it, but not quite so proud of the 3 other groups out at >1.125" in that string. Last week, I had a much better target. 6 groups, all between .375 and .75 inches. I'm finally getting the hang of consistency in hold, sight picture, trigger control and follow through. Mind you, I knew all this from the get go. Just took a few hundred rounds to build the muscle memory back in. It doesn't happen in a couple of 15 shot range sessions. If it was easy, we'd all be shooting bug holes.
I expect a big drop in performance when I start moving to longer ranges as I'm gonna have to learn to read wind all over again. It's different with a scope vs the naked eye. My eyes, at 71, ain't what they used to be either.
I just picked up a 22 LR trainer that I'm going to build into a practice gun. I just missed getting a cherry Anschutz 64 but I'm gonna build a CZ into something sweet. Allows me to work at much less cost though. Good match ammo for my gun is near $2.00 per shot. I can shoot a whole afternoon for the cost of 2 boxes and I'll learn a whole bunch more about the evening breeze as well.