Rlandry, The 22-250 is a very popular varmint cartridge, but yes, probably not the most popular here. That aside, I have an older Remington 700, 1-14 twist similar to yours. So far, I've had the best results with a 55 grain Hornady V-Max. Others swear by the 40-50 grain bullets... I'd love to be able to get the 53 grain V-Max to shoot well out of mine, but, so far, not much luck there..... So, my advice, your best bet will probably be the 40-55 grain bullets!!!! Good Luck, Idaho-5R