I dropped a few Antelope with the 178 Amax 44.4 Varget Lapua wlr 2.828 ~2650 @ 4700 feet.
500Y SPS tactical 1:12 11 moa drop, DRT lung shot
250 Y neck shot, took a few steps and dropped.
The key when using highly frangible bullets is range, velocity, Sectional Density, placement. A 308 with 178 or a 7mm-08 with a 162 and you are good for various ranges. A 300 with a 168 amax at close range and you have more potential for meat damage (especially if you hit a shoulder).