Re: 22-250 Ackley build
Mine is a 14 twist so I can't shoot the heavy stuff. I'm getting 3800 with 50 gr V-Max's for a fireforming load. I've just been forming up a pile of brass before I work on the fun load. I know that once I start shooting the full power load, I won't want to go back to shooting the fireform loads.
I would say that 3850 would be a little high though if I had to guess. I can't say for sure as I can't shoot them.
Good luck and have fun with it. I'm sure you'll love it as much as I do mine.