Yes, just buy some round nose or flat nose flatbase bullets and you will be fine. I've a 22" an 16.5" 12 twist I shoot to 500 w/o issue using a cast load I have come up with. That said I've shot the Sierra 180 gr prohunters over 10.4-.6 of trailboss to the same distance w/o issue. Those that say a 12 twist will not shoot a sub are flat out wrong. It's all about bullet shape first, twist second. Weight has a little to do with it but the first two more so. I went to my cast bullet load (Lyman 311332BV & Red Dot)as it is a semi pointed and takes less up to 500 vs a true round nose or flat nose. I do not have a dedicated sub gun as I have sub loads, for every stick I own from .223 to 300wm. Depending where you shoot the most your DA an SOS will dictate where your max muzzle vol needs to be. That said I have 2 loads one for a very low DA and one for a normal higher DA. My max at the muzzle is 1090 an lower max is 1010. If you use a flat nose the pressure wave is different than a round nose, an both are totally different than my semi pointed. You can get the crack at a lower muzzle speed with the round an flat vs the semi.