Even at 100. the wind will have some effect, not very much but something you should be able to measure. I have chosen a 6.5 as my primary caliber. My target rifles weigh in excess of 13 lbs and I could be shooting 308 at that weight and not really notice very much difference. My two other rifles for shooting within that distance range are an SR15 in 5,56 or an old Mauser custom in 243 that weighs right at 10 lbs. Now for hunting when you are lugging the rifle around all day, even the 10 lb rifle will be a burden on a long day of hiking and shooting, not to mention you have to carry it back along with most of a dead deer. At the 6 odd pounds of a typical hunting rifle the recoil difference will be profound unless you add a brake to the 308 in which case, nobody will hunt with you. My old LWRC REPR with a tank style brake once knocked the hat off a range officer walking 6 feet behind me. 18" bbl and that tank style brake shooting 168g Federal Match.