It sounds like your friend has ignition issues.
I've owned a total of 5 TRG rifles (2-42's and 3-22's). I shoot with several friends who also own TRG rifles. A TRG will go a long way without cleaning and still hold .5 moa. Copper wash in the bbl is normal and should not affect accuracy. Without exception, all of my rifles shoot best when they are dirty (40 rounds or more). They aren't benchrest rifles, they're field pieces.
Get him to stop cleaning, find a load that works, and start shooting. </div></div>
Are you talking about primers or bad powder?
Both my buddy and I can attest to what the TRG can do. Both of us have TRG 22 rifles that shoot! That is one of the reasons he purchased the used 338LP, while on a shooting trip in the mid-west.
I am concerned more so about the increase in pressure readings (3,100 + fps) with closely monitored handloads, then the continue to shoot for accuracy approach. I think a new barrel is the cure, but could be wrong. That's why I posted here before suggesting a rebarrel.
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Are you indicating 3100 fps with 300 gr Scenars? That sounds hot even with a 250 gr. Try cleaning it and shooting some factory ammo out of to see what it does before throwing another barrel on it.