I do like Barnes TSX, the TTSX are just as good, but better BC. BC isn't that important in Africa - if you need extra BC, then that is probably a shot you want to get closer on.
I wish Barnes still made the MRX - that was a very good bullet for long shots, and penetrated better than anything. I still have a few boxes of those, but don't bring the 300 WM anymore, don't need it, the 375 is pretty much everything. On the small stuff like springbok, just shoot to miss bone. I have several springbok and steinbok shot with 375 TSX, very little damage.
I do prefer the 300 grain though in the 375 H&H, just like heavy for caliber stuff, and it has worked well so far. More elevation is just a twist away, no worries. And if I run into a big nasty, I know it works on that too.