In my eariler life I was a hunting guide (mostly elk hunts) up in the Jemez mountains area of New Mexico. Lived on a ranch up there that would bring in well heeled high roller types from back east & California for big dollar multi day guided hunts. These guys would come in with everything from 375's to 378 & 460 Weatherby magnums, absolutely beautiful rifles, gorgeous wood, hand carved leather slings, etc. We'd pack 'em in on horseback and load up their gear & booze, up thru line camps in the mountains. It was halarious to watch these guys shoot those cannons, their flinch was so bad (we'd have them check zeros at base camp), I mean it was pathetic, my assistant guide & I exchanged "a lot of looks" over the course of fall & early winter. The 06's remingtons we carried as saddle guns looked like they had been through two world wars but they were clean and accurate. They were our personal guns and all we could afford back then. We fed the ranch and camps with those rifles all late summer through 6 months of work & took a shit load of meat out of those mountains with those old beat up '06's (things were a little different back in those days lol). So I know a little something about watching guys shoot big caliber lightweight rigs & I can tell you the frequency of misses and really terrible hits on game was more the norm than not. I guess for me, the point is, is a 375 H&H a great tool in the hands of a PH? You bet. In the hands of the average occasional part time or once a year hunter? Not so much. Every once in awhile a guy came in that could really handle his weapon and it was always a pleasure to make their aquaintence but it was a rare exception rather than the rule. I mean these days, depending on where you live, you can go years between getting the draw for a hunt. And I can tell you none of those guys were going to hit a gopher with a 378 Weatherby lol! My advice to the op is pick a rifle & caliber you can (and WANT TO) shoot alot and become really proficient with without dreading & developing a real dislike for the experience. Once you develop a flinch it's a hard habit to break for most. Where I live now elk are almost as thick as jackrabbits and based on my experience and run ins with hunters, most are taken with 270's, 06's & 308's by the locals. The "out of towners" bring in the boomers and really loud ATV'S and are almost always lost lol. I guess some things just never change.........Anyway, just my take on it.