Maybe, but I sure have tried.
I recently worked up a load (Newberry OCW) for a new 6 BRA using 105 Hybrids 015 off. Familiar with rough starting weights, I only ran it with a few grains difference start to finish. The results were pretty obvious, the plots favored 31.0 grains of Varget at 2920 fps. 31.0 gr. shot .16" (Probably coincidental the smallest group was in the center of the node.) With the Newberry method of round robin shots, I don't think it coincidental that every 5th shot of 40 landed in the same hole.
I next tried playing with seating depth changes, 003 at a time out to around 060 and remarkably I found no appreciable difference, certainly none shot smaller.
I've done this with 223 SMKs , 75 ELDMs, and 6 & 6.5 Berger Hyrbids - and always found the charge weight to produce the most significant advantage over seating depth.
I'm certainly not arguing against the theory, I just haven't found it to show in practice. The targets below represent the results of OCWs and just shooting the same seating depth (With the 223 & 6.5 until the barrels were toast).
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