I can assure you the Vmax WILL NOT PERFORM at subsonic velocities, at least not in water tests. I fired several into 6 milk jugs of water lined up. Punches a hole through about 3 jugs and stops in the 4th-and I could probably re-use the bullet. It was not deformed at all except the engraved rifling marks. Most any jacketed bullet designed to leave the barrel above 2000 fps will not mushroom or otherwise perform like it is designed to do at 1050 fps. This is not to say a well placed round won't kill, but you completely lose every advantage of having a high-velocity round when you go subsonic. And velocity is what makes these small calibers shine. Many animals react like they were struck by lightning and are DRT with these fast bullets--but slow that bullet down and the magic is gone.
CCI 22LR subsonic HPs, on the other hand performed admirably in the water tests. The HPs mushroomed perfectly and the first jug exploded like it had been hit with a 223 full house load. The bullet went on through the second jug, which had a 3" split at the entrance hole, and punched a neat hole in the 3rd jug where it stopped.
The CCI SEGMENTED HP subsonic performed just as designed as well. First jug blew up and the bullet separated into 3 equal slivers, 2 of which remained in the first jug and one penetrated into the second jug. Just as it was designed to do.
If you HAVE to be quiet, I would put much more faith in the subsonic 22LR HP than the 224 dia Vmax at subsonic speeds. Hitting tissue rather than water may well cause a greater upset in these bullets, but I ruled them out after the water tests. Since this test, any animal shot with a jacketed bullet is shot with a full power load around my house. My suppressor works very well at reducing muzzle blast, and the supersonic crack is about as loud as an un-suppressed 22LR with high velocity ammo. Also, the POI is about a foot low from normal at 100 yds, whether it be 223 or 308.
If that's not enough, the bullets that are designed to be launched at 3000+ fps may not stabilize well at such low velocity and cause baffle strikes.
Now, if you decide to go with a larger caliber (at least .30) then you can load a heavy bullet and have a much greater effect on game. Flat nose bullets will impart greater shock value, and the heavy bullet will retain enough energy to drive it deep. Like real estate, location location location--bullet placement is key.
All this summarized: By reducing your 22-250 to subsonic velocities, you will reduce terminal performance to a level considerably lower than subsonic 22LR HPs are capable of.
Subs are fun for shits and grins and impressing your friends with your suppressor, but for serious use and humane taking of game or varmints you are severely handicapped when using smaller calibers. All the foregoing is strictly my opinion and I'm sure there are many who would disagree, but that's my story and I'm stickin to it.