If you are talking purely about getting the best accuracy I wouldn't mix jacket types in the bore without a cleaning, nor would I shoot different powders without a cleaning. That said, my accuracy demands are not so rigid that I need worry about those things.
In what situation? Having never 'cut the pie' or crossed a 'fatal funnel'? I can show you how to do it in ten minutes; and then you've done it. The fact that there was never a real person in the room while you did it makes no difference.
That was merely an example. We are off topic and I don't wish to argue. Suffice to say, a 10 minute school circle with a guy (NOT YOU) who has never been in a gunfight means diddly in your percentage chance of living through CQB with a trained/armed enemy. Lots of folks have spilled a lot more blood and have the experence and know how where some of these guys market training for being a "gunfighter" when they themselves don't even know what they would do in said situation because they have never been on a 2 way range.
I am not speaking of Tubbs or Hodnett here. A lot of these guys making big bucks off "gunfighter" schools are questionable at best. I have even worked with some more experienced folks that a simple arty sim, IED sim and mini bang really wreaks havoc just adding a little chaos. Again, it has not a thing to do with you Graham, just a little venting on swollen marketing.