The first time I got it, the nurse missed my vein for the IV. I'm on the table saying hi everyone! Dr says I got two grains... I should be out. Then notice IV not right. 2nd try, 2 more grains and good to go. I went home and slept for 12 hours. Best sleep of my life.When it's titrated properly, it's quite effective. I had it for my colonoscopy as well. It's all they needed. But it's also used in the "general anesthesia" triad for the actual anesthesia portion. It's usually some Fentynal derivative for the Analgesia portion and Iso-Florane gas for the amnesia.