Yes I have and buckles too to include one pack on its maiden trip.
Zipper teeth jumped timing and left a gaping hole, weather / water found its way in.
Laid pack down to access, zipped open, stuffed pack full again, pulling on zipper the carrier came off the track, no way to zip it closed with a giant hole in the pack, webbing and duct tape was used to secure it closed. Repair kits are sold but in the field, its easier said than done but it can be done.
Carrying heavy over-sized over-stuff pack popped a zipper open.
Others disagree but my experience says zippers on a pack have little value especially on large volume packs. The idea to access kit inside does not actually come to fruition in the real world. What is so important inside that you have to unzip to access it? If this is, then place the kit somewhere else. My main body was packed with the big over size heavy kit that I did not have a reason to access on the fly. For high demand kits on the fly, I found an easier point of entry so the kit could be accessed on the fly without removing my pack or unzipping it. Are there occasions, yes but over my decades of use they are rare and just remove pack, pull top kit out, access what you need. You just about have to lay the pack on its frame to access and then rezipper it shut. Zippers are a weak point. They leak.
I have a TT Removable Operator pack with zipper for 3 years now and its most def top shelf, on the same shelf as any top pack. Its my carry pack when outing for shooting kit; spotter, ammo, jackets, food / water, fist aid, repair, daily outing kit, etc, zip still good to go but if I went 100 miles out for 2 weeks, it would not be with me.
I had several Andinista packs from WildThings with zippers and mine never ever failed and talking to JB there, they never had a report of zipper fail since 1986. But, like him, I had one stitched up with no zipper because it was not needed and just added more weight.
The pack in question is quite heavy for a 3100 pack. I live by and taught; light is right, lighter is righter and lightest is rightest. A light weight quality pack does not fail. My technora Andinista weighed in the 2+ for 4000ci still running hard. But is a solid pack so if you want it get and use it but since you asked about zippers failing, not always but yes they do and at the wrong time and place.
good luck