That could be anything. How did you develop the load you are shooting?
These are the items I would look at if it was me.
-Are you shooting a load that is in the node? Many times you can load rounds that are not in a node and get good 3 shot groups (1/2" or under) possibly even 5 shot groups but you will have a flyer, likely at least one or two in a 5 shot group.
-Chrono your round, this should be another indicator if you are in a mode or not.
-Is it you, are you pulling the shots?
-Check that everything is tight on scope mounts and the scope itself is not broke (what scope is on rifle?). Parallax adjusted correctly? Mirage?
-Make sure barrel is not touching anything on stock
-Is the barrel a thin contour? Are you getting a couple good 5 shoot groups then it opens up? If barrel is smaller contour and your shooting 15 rounds or so in a row, it might start heating up by those last couple shots causing flyers.
-Do you have consistent reloading practice. Are all you bullets sized, seated, trimmed, etc. all the same?
-Was the rifle chambered by someone reputable? Can the rifle shoot, have you shot any groups with factory loads?
Those are some things I would check. There are other thing but those are where I start. Many things in that list are obvious but since I don't know you and since all of us overlook simple stuff once in awhile I listed the obvious stuff as well. Not trying to degrade you or nothing because I am learning myself.