It's a gas operated gun - so a powder that produces more gas will make it cycle easier. H110, No 11 FS, etc. Alliant 2400 doesn't produce as much gas, and would naturally require a hotter load to get it to cycle, than a comparable load with H110.
On the other hand, load it up with a fast burning powder that doesn't make a lot of gas, and you'll be way over pressure long before it'll cycle. Anybody that says you can't blow one up just doesn't know what they're talking about. If you don't believe me, try a case full of Titegroup and stand behind a tree; I can pretty much guarantee that it won't cycle, and it will blow up.