They are especially well suited for reloading small pistol cartridges.
With wery low pressure small rifle cartridges they May be ok but... There have been several posts on this subject recently regarding which of those low pressure cartridges they may be used. .223 typically isn't one of them.
You have only have two eyes and two sides of your face: some people may do fine with only one each, I'm guessing you'd like to keep yours more or less the way they are.
One primer is taller than the other...i can't remember which one it is...but basically it would mean you'd have to ream primer pockets to compensate for the difference in tolerances. Personally I wouldn't bother because then you'd have batches of cases with pockets for small pistol and cases with pockets for small rifle.
I did this once on accident when I was new to reloading. The only thing that was funny was that the loads were about 200 fps slow when I chronoed them and I couldn't figure out why. Then I noticed I had been using the wrong primers. Doh!