Honestly, if we just took about 40 miles of the other side of the border it would seriously fuck a lot of shit up. There's a lot of black market infrastructure and personal connections in that area specifically, to traffic into the USA. Maybe give it back to them, maybe don't. Big dick move and all, but fuck, their entire country wants to be Americans anyway.
Venezuela should be integrated and turned into a stable government like Peurto Rico if we give so much of a hot fuck about them. Kill communism and reap the rewards of Venezuelan resources and allegiance, get two birds stoned at once. Frankly, the only pause I have is that I can find no immediate potential for elevating their society to a point where the Venezuelan people would be overtly constructive to American values at home. They have communism for a reason, sadly. Economically and strategically, however, they are useful.